This project aims to characterise the microbiota and inflammation underlying immune dysregulation in patients with humoral immunodeficiency. In a cross-sectional cohort, gut and respiratory tract microbiota, mucosal defence, cytokine levels, immune cell subsets, and clinical data will be analysed. Patients included are diagnosed with CVID, XLA, selective IgA deficiency, or are healthy controls.
16S rRNA sequencing
Shotgun metagenomics sequencing
Immune fluorescence microscopy
Fluorescence in situ hybridization
Olink Proximity Extension Assay