Deficiency or deregulation of the immune system can lead to a kaleidoscope of clinical features which are genetically determined or induced by infections or cancer therapy.
During this course, lectures and tutorials will focus on four main topics:
2. Autoimmune diseases and atopy
4. Tumor Immunology
Course aims and content
Knowledge & insight:
At the conclusion of this course, the student has the ability to
- Relate immunological principles, clinical consequences, therapies and new evelopments of some disorders (Innate immunodeficiencies and AIDS, Atopy and Autoimmune diseases, Transplantations and Tumor immunology).
- Render examples and principles of animal models, applied to rheumatological research and new therapies in rheumatic disorders.
- Describe the role of regulatory T cells in atopy and autoimmune diseases.
- Explain the mechanisms of (some types of) chronic inflammatory reactions.
- Coherently describe the relationship between tumor and immune system of the host.
At the conclusion of this course, the student must be able to present, at the level of a (fledgeling) scientist
- A coherent, clearly structured, critical survey of one or more scientific articles, which discusses strong and weak points, and pro’s and con’s, of a methodological approach and/or a presented concept.
At the conclusion of this course, the student must be able to exhibit
- A critical and inquisitive attitude towards claims concerning animal models and immunopathogenetic concepts.
- A respectful and cooperative attitude towards those with whom the student prepares presentations and conducts discussions.
Literature / study material used
Immunology: Kuby et al. 6th edition, 2006, W.H. Freeman & Company
Useful other books:
Robbinson - Pathologic Basic of Disease, 7th edition
Alberts - Molecular Biology of the Cell, 4th or 5th edition